In this study, we aimed to investigate the value of DDC in assessing the status of lymphovascular invasion in patients with rectal cancer. Ninety-eight patients with rectal adenocarcinoma underwent DWI with 16 b-values at 3.0T MR system. We found there was an significant difference in DDC value between the LVI presence group (DDC=0. 893±0.151×10-3mm2/s, n=46) and the LVI absent group (DDC=0. 825±0.127×10-3mm2/s, n=52), (P=0.018). We speculate that DDC value derived from multi-b value DWI could be a useful functional parameter in detecting the status of LVI in rectal cancer patients.