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Abstract #4991

Noninvasive Measurement of Calf Muscle Perfusion Immediately after Plantar Flexion Exercise in Elderly Patients with Heart Failure and Preserved Ejection Fraction

Robert A. Kraft1, Craig A. Hamilton1, Peter H. Brubaker2, W. Scott Hoge3, M. Constance Linville4, J. Thomas Becton5, Richard J. Thompson6, Mark J. Haykowsky7, and Dalane W. Kitzman5

1Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, United States, 2Health and Exercise Science, Wake Forest University, Winston-Salem, NC, United States, 3Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 4Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, United States, 5Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, United States, 6Bioengineering, University of Alberta, Edmonton, Canada, 7College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX

The pathophysiology of Heart Failure Patients with Preserved Ejection Fraction is poorly understood but there is increasing evidence that skeletal muscle blood flow and metabolism play important roles in this disease. Accurately and non-invasively measuring skeletal muscle blood flow with sufficient temporal resolution to measure skeletal muscle blood flow dynamics in individual muscles is challenging. We present a optimized version of pseudo-Continuous ASL capable of measuring blood flow map of the calf every 16 seconds. Data from two healthy adults is presented.

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