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Abstract #4990

A quantitative relationship between R2* and deoxyhemoglobin levels in calf muscle

Kexin Hao1, Gwenael Layec2, Corey R. Hart3, Christopher C. Conlin4, Kristi Carlston4, Vivian S. Lee4, and Jeff L. Zhang4

1Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, United States, 2Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States, 3Department of Exercise and Sports Science, University of Utah, UT, United States, 4Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

This study examined the relationship between R2* measurements from BOLD MRI and deoxyhemoglobin (HHb) measurements from near-infrared spectroscopy (NIRS) in calf muscle of subjects with varying degrees of peripheral artery disease (PAD). Following plantar-flexion exercise, the time required for R2* and HHb to recover to resting-state values was recorded. Linear regression was used to relate recovery time between R2* and HHb. This quantitative relationship enables estimation of HHb from MRI-measured R2*, which can help to improve the assessment of PAD since MRI can easily be performed for muscle tissue that is too deep for NIRS evaluation.

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