Abstract #4990

A quantitative relationship between R2* and deoxyhemoglobin levels in calf muscle

Kexin Hao¹, Gwenael Layec², Corey R. Hart³, Christopher C. Conlin⁴, Kristi Carlston⁴, Vivian S. Lee⁴, and Jeff L. Zhang⁴

¹Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, United States, ²Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States, ³Department of Exercise and Sports Science, University of Utah, UT, United States, ⁴Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

This study examined the relationship between R₂* measurements from BOLD MRI and deoxyhemoglobin (HHb) measurements from near-infrared spectroscopy (NIRS) in calf muscle of subjects with varying degrees of peripheral artery disease (PAD). Following plantar-flexion exercise, the time required for R₂* and HHb to recover to resting-state values was recorded. Linear regression was used to relate recovery time between R₂* and HHb. This quantitative relationship enables estimation of HHb from MRI-measured R₂*, which can help to improve the assessment of PAD since MRI can easily be performed for muscle tissue that is too deep for NIRS evaluation.

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