Meeting Banner
Abstract #5001

Development of an MR-Compatible Ergometer for Use in Quantifying Human Skeletal Muscle Bioenergetics During Supine Dynamic Contractions of the Knee Extensors

Rajakumar Nagarajan1, Youssef Jaber2, Miles Bartlett3, Liam F Fitzgerald3, Julia Miehm3, Frank C Sup IV2, and Jane A Kent1,3

1Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, 2Department of Mechanical & Industrial Engineering, University of Massachusetts, Amherst, MA, United States, 3Kinesiology, University of Massachusetts, Amherst, MA, United States

The goal of this project was to develop an MR-compatible, multi-modal ergometer for the reliable measurement of human skeletal muscle torque, velocity, power and joint angle during 31P MRS studies of knee extensor muscle energetics. Intracellular [PCr], [Pi] and pH were determined in the vastus lateralis with 4-s time resolution during 4 min of maximal voluntary isokinetic contractions at 240 degrees per second, with a 30 degree range of motion. High S/N for both the MRS and power data indicate that this tool will be useful in future studies of in vivo muscle bioenergetics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here