The goal of this project was to develop an MR-compatible, multi-modal ergometer for the reliable measurement of human skeletal muscle torque, velocity, power and joint angle during 31P MRS studies of knee extensor muscle energetics. Intracellular [PCr], [Pi] and pH were determined in the vastus lateralis with 4-s time resolution during 4 min of maximal voluntary isokinetic contractions at 240 degrees per second, with a 30 degree range of motion. High S/N for both the MRS and power data indicate that this tool will be useful in future studies of in vivo muscle bioenergetics.
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