Abstract #5001

Development of an MR-Compatible Ergometer for Use in Quantifying Human Skeletal Muscle Bioenergetics During Supine Dynamic Contractions of the Knee Extensors

Rajakumar Nagarajan¹, Youssef Jaber², Miles Bartlett³, Liam F Fitzgerald³, Julia Miehm³, Frank C Sup IV², and Jane A Kent^1,3

¹Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, ²Department of Mechanical & Industrial Engineering, University of Massachusetts, Amherst, MA, United States, ³Kinesiology, University of Massachusetts, Amherst, MA, United States

The goal of this project was to develop an MR-compatible, multi-modal ergometer for the reliable measurement of human skeletal muscle torque, velocity, power and joint angle during 31P MRS studies of knee extensor muscle energetics. Intracellular [PCr], [Pi] and pH were determined in the vastus lateralis with 4-s time resolution during 4 min of maximal voluntary isokinetic contractions at 240 degrees per second, with a 30 degree range of motion. High S/N for both the MRS and power data indicate that this tool will be useful in future studies of in vivo muscle bioenergetics.

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