Meeting Banner
Abstract #5031

Imaging and Quantification of Grafted Mesenchymal Stem Cells in Rat Knee Joint

Sergey Magnitsky1, Jaskanwaljeet Kaur1, Yu-An Evan Lay2, Geetha Mohan2, Jinjin Zhang3, Djaudat Idiyatullin3, Michael Garwood3, and Nancy Lane2

1Radiology, UCSF, San Francisco, CA, United States, 2Center for Musculoskeletal Health, UC Davis, 3Radiology, University of Minnesota

Mesenchymal Stem Cells (MSCs) have high potentials for a treatment of bone diseases. T2*w-MRI in combination with iron labeling of MSCs has shown promising results for the detection of therapeutic cells. However, this method is not applicable for the detection of MSCs in knee joints because both the iron labeled cells and bones produce a hypointense signal. We have shown that the SWIFT sequence overcomes this limitation and generates a distinct and quantifiable signal from iron labeled cells in a knee joint in vivo. Proposed protocol opens new opportunities for in vivo monitoring of cell therapy of bone disorders.

This abstract and the presentation materials are available to members only; a login is required.

Join Here