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Abstract #5045

Dynamic Monitoring of Brown Adipose Tissue Activation and White Adipose Tissue Beiging

Gregory Simchick1,2, Amelia Yin3, Hang Yin3, and Qun Zhao1,2

1Physics and Astronomy, University of Georgia, Athens, GA, United States, 2Bio-Imaging Research Center, University of Georgia, Athens, GA, United States, 3Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States

The treatment of obesity is clinically significant as it is related to many serious heart diseases and diabetes. Therefore, it is very advantageous to be able to non-invasively monitor whether or not a treatment is effective. Presented here is a method using magnetic resonance imaging (MRI) based water-fat separation, quantitative susceptibility mapping (QSM), and transverse relaxation rate ($$$R_{2}^{*}$$$) to dynamically monitor brown adipose tissue (BAT) activation and the white adipose tissue (WAT) beiging process. In a mouse model, increases in susceptibility between 40-164% and increases in $$$R_{2}^{*}$$$ between 32-71% were observed in intracapsular BAT and inguinal WAT indicating metabolic changes related to BAT activation and WAT beiging.

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