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Abstract #5046

Optimal Control Pulse Design for Contrast in MRI: in vivo applications

Eric Van Reeth1, Hélène Ratiney1, Sophie Gaillard1, Michael Tesch2, Olivier Beuf1, Steffen Glaser2, and Dominique Sugny3,4

1CREATIS - CNRS UMR 5220 - INSERM U1206 - Université Lyon 1 - INSA Lyon - Université Jean Monnet Saint-Etienne, Villeurbanne, France, 2Department of Chemistry, Technische Universität München, Munich, Germany, 3Laboratoire Interdisciplinaire Carnot de Bourgogne, Dijon, France, 4Technische Universität München Institute for Advanced Study, Munich, Germany

Optimal control RF pulse design has recently been proposed to address the optimization of image contrast in MRI - in order to explore the theoretical contrast bound of a given imaged system. Their use has recently been validated on a real MRI scanner to contrast various in vitro samples. This abstract extends these results to in vivo applications, and shows that contrasts obtained with standard weighting strategies on rat and mouse brains can be improved or inverted. This demonstrates both the interest and flexibility that one can get when using optimal contrast pulses for in vitro and in vivo applications.

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