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Abstract #5048

Optimal MRI pulse sequence to quantify iron-oxide nanoparticles at high concentration

Jinjin Zhang1, Michael Garwood1, and Djaudat Idiyatullin1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Recent advances in nanotechnology have allowed for the effective use of iron oxide nanoparticles (IONP) in magnetic nanoparticle hyperthermia for cancer therapy and in cell tracking for immunotherapy. Noninvasive imaging techniques for tracking and quantifying IONPs in-vivo will be necessary for accurate assessment. In this study, we have tested four representative ultra-short T2 sensitive MRI pulse sequences, UTE, ZTE, SWIFT and MB-SWIFT, to compare their performance for measuring IONPs at clinically relevant high concentration range. Multiple performance metrics were evaluated, compared, and summarized.

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