We demonstrate the clinical feasibility of high-resolution (HR) in-vivo mapping of proteoglycan water fraction (PgWF) in human knee cartilage by combining the mcDESPOT protocol for data acquisition and Bayesian Monte Carlo (BMC) analysis for data analysis. For all subjects, PgWF maps derived from low resolution datasets exhibited partial volume and magnetic susceptibility effects leading, respectively, to an overestimation and an underestimation of PgWF values in several cartilage regions. These issues were absent in HR PgWF maps. Further, BMC-mcDESPOT demonstrates high reproducibility and stability in the estimation of PgWF as compared to the conventional stochastic region contraction (SRC) algorithm.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords