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Abstract #5093

UTE-MT Imaging Can Reliably Evaluate Macromolecules in MSK Tissues: A Sequential Collagenase Enzymatic Treatment Study

Xin Cheng1,2, Yajun Ma1, Eric Y Chang1,3, and Jiang Du1

1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2Department of Histology & Embryology, Jinan University, Guangzhou, People's Republic of China, 3Radiology Service, VA San Diego Healthcare System, CA, United States

In this study, we aimed to evaluate UTE-MT derived macromolecule fractions in articular cartilage subject to sequential collagenase enzymatic treatment. The preliminary result suggests that UTE-MT imaging and signal modeling allows for quantitative evaluation of macromolecular fractions in articular cartilage. Furthermore, results from UTE-MT imaging and signal modeling are insensitive to the magic angle effect, which is a huge advantage over the conventional T2 and T1rho measures. The water and macromolecular changes in both short and long T2 tissues in the knee joint using UTE-MT provides a “whole-organ” approach, and may be useful in the diagnosis and treatment of OA.

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