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Abstract #5097

Efficacy of GelrinC in the treatment of chondral and osteochondral lesions: MRI results based on semi-quantitative MOCART scoring and T2 mapping

Markus Schreiner1,2, Kitty Ohel3, Livnat Ben-Zur3, Sebastian Röhrich2, Martin Zalaudek2, Pavol Szomolanyi2, Vladimir Juras2, Vladimir Mlynarik2, Reinhard Windhager1, and Siegfried Trattnig2,4

1Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 2High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3Regentis Biomaterials Ltd, Or Akiva, Israel, 4CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

The treatment of femoral cartilage lesions still remains a challenge. Established cartilage repair techniques include microfracture (MFX), acellular scaffolds and cell based therapies such as ACI and MACI, which differ in associated morbidity and outcome. Therefore, there have been strong research efforts to develop novel treatment alternatives. In this study, we demonstrate that GelrinC, a novel acellular biodegradable implant, allows a successful treatment of both chondral and osteochondral femoral lesions in a minimal invasive one-step procedure. For both lesion types a substantial improvement of MOCART scores as well as T2 values has been demonstrated over a 24-month period.

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