Abstract #5111

Does Free Water T1 Differ in Different Regions of Human Cortical Bone? A Clinical Quantification Approach

Atena Akbari^1,2, Shahrokh Abbasi-rad^1,2, Amirali Kazeminejad^1,3, and Hamidreza Saligheh Rad^1,2

¹Quantitative Medical Imaging Systems Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran, ²Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran, ³School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran, Tehran, Iran

MR structural imaging is proved to be able of featuring cortical bone hierarchical structure by obtaining enough signal from hydrogen protons of short T₂^* components of bone. Extreme variability of free water quantities found in cortical bone pores during aging or bone disease, furnishes researchers with a great source of information to inspect bone health. In this study, we employed short time of echo MR imaging approach to quantify cortical bone free water T₁ in different regions of tibia to extract the porosity distribution pattern of cortical bone and its alteration with age in eight healthy volunteers.

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