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Abstract #5112

MRI study of the changes of perfusion and fat content in radiation-induced bone marrow injury in rats

kejun wang1, Yunfei Zha1, and Xiao Xu2

1Department Of Radiology, Renmin Hospital Of Wuhan University, wuhan, People's Republic of China, 2GE Healthcare, Shanghai, People's Republic of China

This study is to investigate whether adipocytes influence bone marrow microcirculation based on DCE-MRI and ex vivo high-resolution MAS 1H NMR spectroscopy. In this animal review committee-approved study, Rat Femurs were evaluated through DCE-MRI, 1H HRMAS NMRS, and histopathologic analysis before irradiation and on days 4 and 7 after irradiation. The results showed Ktrans and adipocytes gradually increased a peak on the 7th day after irradiation. In conclusion, bone marrow microcirculation permeability correlation with fat content after irradiation suggested for the first time that a pathophysiology mechanism based on fat- vascular permeability in the injury of bone marrow microcirculation.

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