Purpose: To identify MR parameters that are significantly associated with aging in healthy thigh muscles and investigate age-related characteristics.
Methods: Thirty healthy subjects underwent multi-parametric MRI of the right thigh, including IVIM-DWI, DTI, multi-echo Dixon imaging, DCE-MRI. Parametric maps of the thigh muscles (divided into three compartments) were analyzed. Relationships between parameters and age were assessed with simple and multiple linear regression analyses.
Results: Fractional anisotropy (slope=1.018) and Ve (slope=2.151) in anterior compartment and fat percentage in posterior compartment (slope=2.031) showed significant relationships to age (p<0.05).
Conclusion: Several MRI parameters of the thigh muscles were associated with normal aging.