Abstract #5125

Age-related changes in healthy thigh musculature: Multi-parametric MR imaging analysis

Min A Yoon¹, Suk-Joo Hong¹, Chang Ho Kang², Kyung-Sik Ahn², Baek Hyun Kim³, and In Seong Kim⁴

¹Department of Radiology, Korea University Guro Hospital, Seoul, Korea, Republic of, ²Department of Radiology, Korea University Anam Hospital, Seoul, Korea, Republic of, ³Korea University Ansan Hospital, Gyeonggi-do, Korea, Republic of, ⁴Siemens Healthcare Korea, Seoul, Korea, Republic of

Purpose: To identify MR parameters that are significantly associated with aging in healthy thigh muscles and investigate age-related characteristics.

Methods: Thirty healthy subjects underwent multi-parametric MRI of the right thigh, including IVIM-DWI, DTI, multi-echo Dixon imaging, DCE-MRI. Parametric maps of the thigh muscles (divided into three compartments) were analyzed. Relationships between parameters and age were assessed with simple and multiple linear regression analyses.

Results: Fractional anisotropy (slope=1.018) and V_e (slope=2.151) in anterior compartment and fat percentage in posterior compartment (slope=2.031) showed significant relationships to age (p<0.05).

Conclusion: Several MRI parameters of the thigh muscles were associated with normal aging.

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