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Abstract #5198

MRI Quantification of Liver Proton Density Fat Fraction during Free Breathing using a Motion-Insensitive Single-Shot 2D Technique

B. Dustin Pooler1, Jeannine A. Ruby1, Diego Hernando1, Ann Shimakawa2, and Scott B. Reeder1

1University of Wisconsin, Madison, WI, United States, 2GE Healthcare, Waukesha, WI, United States

Chemical shift encoded (CSE-MRI) techniques have been previously validated for the measurement of liver proton density fat fraction (PDFF), which serves as a biomarker for liver fat content. However, current CSE-MRI techniques rely upon 3D volumetric or 2D interleaved acquisitions, both of which are sensitive to motion and require the patient to suspend respiration. In this study, we demonstrate the feasibility of a "single shot" 2D sequential CSE-MRI technique to freeze motion. 2D sequential CSE-MRI demonstrates superior performance during free breathing when compared to 3D and 2D interleaved acquisitions.

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