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Abstract #5199

Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise

Cheng William Hong1, Gavin Hamilton1, Catherine Hooker1, Charlie C Park1, Calvin Andrew Tran1, Jeffrey Schwimmer2, Scott B Reeder3, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Pediatrics, Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, CA, United States, 3Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States

Non-zero proton density fat fraction (PDFF) is commonly observed in the spleen on chemical-shift-encoded MRI. A prospective assessment in 42 research subjects with no visible fat peaks on MR spectroscopy demonstrated small amounts of splenic fat (PDFF up to 4%) using four different MRI-based fat fraction estimation techniques. These measurements were poorly correlated with each other, implying that fat measurements in spleen are likely artifactual rather than representing true splenic fat.

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