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Abstract #5200

Comparison of MRI techniques for hepatic fat and iron quantification in the UK Biobank study

Chloe Hutton1, Michael Gyngell1, Matteo Milanesi1, and Michael Brady1

1Perspectum Diagnostics, Oxford, United Kingdom

We compared standard Dixon and T2* relaxometry with “IDEAL” for measuring liver proton density fat fraction (PDFF) and T2*, surrogate metrics for steatosis and iron burden respectively. Results in 118 UK Biobank study participants showed very good correlation between the two methods. Dixon PDFFs were consistently lower than IDEAL PDFFs, explained by the 20° flip angle used for Dixon, introducing a T1 bias and deviation from true PDFF values. Results also showed improved image quality for IDEAL, highlighting the strength of this technique to serve as a reliable and simultaneous biomarker of liver fat and iron overload.

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