Abstract #5206

Quantitative measurements of perivascular spaces at 7T, using a semi-automatic tracking method

JM Spijkerman¹, HJ Kuijf², WH Bouvy³, MI Geerlings⁴, J Hendrikse¹, PR Luijten¹, and JJM Zwanenburg¹

¹Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ³Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands

Currently, perivascular spaces (PVS) are mostly investigated with qualitative measures. In this work, PVS in the centrum semiovale were tracked using a semi-automatic method, and PVS length and tortuosity were determined. Univariate and multivariate linear regression was performed for age, number of tracked PVS, PVS length, and PVS tortuosity. The results show that quantitative assessment of PVS beyond counting is feasible, and a significant positive association between PVS length and the number of tracked PVS was found. These quantitative measurements may be more suitable than qualitative methods to investigate PVS.

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