Abstract #5223

Quantitative Evaluation of Micro-vessel Blood Flow in Subcortical Nuclei with High-resolution TOF-MRA at 7T

Xianchang Zhang^1,2, Qi Yang^3,4, Qingle Kong^1,2, Zhaoyang Fan³, Jing An⁵, Rong Xue^1,2,6, and Zihao Zhang¹

¹State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, ²University of Chinese Academy of Sciences, Beijing, People's Republic of China, ³Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Xuanwu Hospital, Beijing, People's Republic of China, ⁵Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, People's Republic of China, ⁶Beijing Institute for Brain Disorders, Beijing, People's Republic of China

TOF-MRA at 7T ultra-high field has been proven to have advantages in imaging the perforating arteries originating from the middle cerebral artery. In this study, a novel method of VOI-based micro-vessel density measurement was developed to quantitatively assess the blood flow in subcortical nuclei. Using this technique, the vascular density (VD) of specific basal ganglia sub-regions can be evaluated. Preliminary results showed that VD values of specific nuclei were different among Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalophy (CADASIL) patients, stroke patients, and healthy volunteers. VOI-based micro-vessel density measurement may be useful in differentiating the etiology of cerebral small vessel diseases.

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