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Abstract #5231

High resolution resting-state functional MRI at 7 Tesla using RF parallel transmission

Xiaoping Wu1, Edward J. Auerbach1, An T. Vu2, Steen Moeller1, Keith Jamison1, Sebastian Schmitter1,3, Pierre-Francois Van de Moortele1, Essa Yacoub1, and Kamil Ugurbil1

1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Center for Imaging of Neurodegenerative Diseases, VA Healthcare System, San Francisco, CA, United States, 3Physikalisch-Technische Bundesanstalt, Berlin, Germany

A major component of the Human Connectome Project (HCP) in the WU-Minn consortium is multiband-accelerated whole-brain resting-state functional MRI (rfMRI) at both 3T and 7T. Although providing better contrast and higher spatial resolutions, the 7T acquisition is compromised by RF nonuniformity. Here, we demonstrate the utility of RF parallel transmission (pTx) for 7T HCP-type rfMRI with 1.6-mm isotropic resolutions. Our results show that pTx can significantly enhance temporal SNR across the entire cortical surfaces and in many subcortical voxels relative to a CP-like-mode RF shimming mimicking single-transmit configurations, thereby holding great potential for acquiring high-quality, high-resolution and high-efficiency rfMRI data.

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