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Abstract #5232

Quantitative assessment of cerebral venous oxygenation in mouse using T2-Relaxation-Under-Spin-Tagging (TRUST) MRI at 11.7T

Zhiliang Wei1, Jiadi Xu1, Peiying Liu1, Lin Chen1, Wenbo Li1, Peter van Zijl1, and Hanzhang Lu1

1Department of Radiology, The Johns Hopkins University, Baltimore, MD, United States

Venous oxygenation level reflects the cerebral metabolic rate of oxygen and its measurement facilitates studies of animal models of diseases. We developed a non-invasive and non-contrast-agent method based on T2-Relaxation-Under-Spin-Tagging (TRUST) to quantify cerebral venous oxygenation in mice at 11.7T. A series of studies were performed to optimize key imaging parameters. This method may prove useful in studies of brain physiology and pathophysiology in animal models.

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