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Abstract #5243

Characterization of laminar profiles in human auditory cortex using a dense 24-channel temporal lobe array at 3T

Pu-Yeh Wu1, Ying-Hua Chu1, Jo-Fu Lotus Lin1, Shang-Yueh Tsai2, Wen-Jui Kuo3, and Fa-Hsuan Lin1,4

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, 3Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan, 4Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland

By using a dedicated 24-channel temporal lobe array and surface based laminar depth analysis, we revealed the tonotopic representations in the human primary auditory cortex on a 3T MRI system. We found that, compared to deep and superficial layers, the minimal inter-subject variability of the tonotopic representation and frequency tuning width were found at the middle layer. Locations in the auditory cortex with finer frequency tuning had smaller inter-subject variability. Taken together, our findings suggested that middle layer of the auditory cortex has more specific frequency preference and selectivity, consistent with neurophysiological animal studies.

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