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Abstract #5247

Study of the PSF distortion correction for ultra-high field BOLD fMRI

Catarina Rua1,2, Myung-Ho In3, Renat Yakupov4, Hendrik Mattern4, Mauro Costagli2, Mark Symms5, Alberto Del Guerra1, Michela Tosetti2,6, and Oliver Speck4,7,8,9

1Department of Physics, University of Pisa, Pisa, Italy, 2Imago7 Research Center, Pisa, Italy, 3Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States, 4Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany, 5GE Healthcare, Pisa, Italy, 6IRCCS Stella Maris, Pisa, Italy, 7Leibniz Institute for Neurobiology, Magdeburg, Germany, 8Center for Behavioral Brain Sciences, Magdeburg, Germany, 9German Center for Neurodegenerative Diseases, Magdeburg, Germany

Distortion correction is an essential step for anatomically faithful analysis of ultra-high-field fMRI data due to strong susceptibility-induced geometric distortions in echo-planar imaging (EPI). Although the point-spread-function (PSF) method allows accurate unwarping and increase in SNR, its effectiveness in modulating the undistorted BOLD signal is still unknown. In this study we applied the PSF-based distortion correction using different types of correction kernels to GRE- and SE-EPI data at different resolutions and directly to the BOLD contrast maps, and evaluated the effectiveness by assessing functional contrast, specificity, and false-positive-rate.

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