In the past years, functional MRI studies in rodents have become more frequent. The signal losses in gradient-echo EPI due to the increased sensitivity to magnetic susceptibility differences at higher magnetic field, however, make fMRI studies of deep brain structures difficult. Here we propose the use of Poloxamer, a non-toxic amphiphilic triblock copolymer well known for its thermo-reversible properties and pharmaceutical application to fill up the air cavities in the rodent middle and external ear canals. This practical method considerably increases geometric fidelity of the functional images, opening up the possibility to longitudinally investigate rodent’s deep brain networks.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords