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Abstract #5249

PRESTO: an alternative to EPI for functional-MRI in rodents

Georges Hankov1,2,3,4, Basil K√ľnnecke2, Markus Rudin1,3,4, and Markus von Kienlin2

1Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, 2Roche Pharma Research & Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland, 3Neuroscience Center Zurich, Zurich, Switzerland, 4Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

With the increasing need for translational readouts, the number of fMRI studies in rodents has grown exponentially in the recent years. Nonetheless, methodological questions regarding fMRI data acquisition in small animals yet have been poorly addressed. In this work, we evaluate the use of the PRESTO sequence for fMRI in rodents: a 3D alternative to EPI using echo-shifting and echo-trains minimizing distortions and artefacts related to the higher magnetic fields, while providing better brain coverage and faster temporal resolution, allowing appropriate physiological noise sampling.

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