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Abstract #5257

Characterize the Effect of Regional Variations in Venule Vasculature Related to Temporal Variability of Hemodynamic Responses Latency at the Human Primary Visual Cortex

Yi-Tien Li1,2, Jo-Fu Lotus Lin1, Pu-Yeh Wu1, Kevin W.-K. Tsai3, and Fa-Hsuan Lin1,4

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Department of Medical Imaging, Taipei Medical University - Shuang Ho Hospital, New Taipei, Taiwan, 3Aim for the Top University Project Office, National Taiwan Normal University, Taipei, Taiwan, 4Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland

We correlated between the temporal chacteristics of the BOLD signals and venule structure at human primary visual cortex (V1). Functional MRI was measured by the high temporal resolution (100ms) simultaneous-multi-slice inverse imaging. Venule probability map was estimated from high spatial resolution (0.85mm) susceptibility-weighted imaging (SWI). Siginficant correlation was found between venule density and intra-/inter-subject temporal variability of the BOLD signal at V1. This correlation suggests that the temporal instability of BOLD signal is likely attributed to vascular structure or reactivity.

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