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Abstract #5258

Gadoxetic acid-enhanced MR imaging of the liver: the effect on hepatic fat quantification in hepatobiliary phase using mDXION-Quant

shuangshuang xie1, qing li1, zhizheng zhuo2, yue cheng1, and wen shen1

1Tianjin First Center Hospital, Tianjin, People's Republic of China, 2Philips healthcare, Beijing, People's Republic of China

This study evaluated the effect of Gd-EOB-DTPA on fat quantification using a multiecho reconstruction technique with T2* correction. Forty-six patients with suspected hepatic tumors underwent Gd-EOB-DTPA enhanced MR imaging and single breath hold 3D mDIXON-Quant for hepatic fat quantification before and 20 minutes after the administration of Gd-EOB-DTPA. Fat fraction (FF) and R2* of the liver parenchyma, spleen parenchyma and vertebral body were measured and compared between pre- and post-contrast. FF measurements of liver, spleen, vertebral body and R2* measurements of liver, spleen revealed no significant difference between the two measurements, and R2* increased in liver and vertebral body significantly after 20 minutes of Gd-EOB-DTPA administration. In addition, good agreement of FF measurement was seen in the Bland-Altman plots. We conclude mDXION-Quant can obtain stable fat quantification in the hepatobiliary phase, without the impact of an increased R2* in liver parenchyma. But R2* maps should be obtained prior to Gd-EOB-DTPA administration.

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