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Abstract #5273

Comparison of BOLD and CBV impulse-response to visual stimulation in humans in the presence of Ferumoxytol

Jacco A de Zwart1, Peter van Gelderen1, Matthew Schindler2, Pascal Sati2, Jiaen Liu1, Daniel S Reich2, and Jeff H Duyn1

1Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States, 2Translational Neuroradiology section, NINDS, National Institutes of Health, Bethesda, MD, United States

Ferumoxytol is a blood-pool-bound superparamagnetic iron-oxide particle (SPIO) that has been shown to yield CBV-dominated fMRI contrast in humans. Differences in impulse-response (IR) timing were previously demonstrated in animals when comparing SPIO-fMRI to BOLD-fMRI. Since BOLD IR is known to differ between humans and animals, we aimed to repeat this SPIO-fMRI to BOLD-fMRI comparison in humans. SPIO-fMRI was performed in human visual cortex and IR was compared to BOLD data from the same subjects. Shorter stimulus onset time and time-to-peak were found. Stimulus design minimized neuronal interaction effects between stimuli; residual inter-stimulus interaction effects, presumably vascular in origin, were found to be minor in SPIO-fMRI, on the same scale as in BOLD.

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