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Abstract #5274

THE IMPACT OF THE LOCAL, MESOSCOPIC FREQUENCY DISTRIBUTION AND DIFFUSION IN GRAY AND WHITE MATTER TO THE STATIC bSSFP SIGNAL PROFILE

Mario Gilberto Báez-Yánez1,2, Philipp Ehses1,3, and Klaus Scheffler1,3

1Department of High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, 3Department of Biomedical Magnetic Resonance, University of Tuebingen, Germany

The phase accumulation that spins experience during a MR sequence is closely linked to the microstructure within the voxel, and basically produces changes in T2* or T2. The present abstract demonstrates how the static bSSFP signal profile is modified by the influence of local susceptibility differences produce by the underlying local-frequency distribution and diffusion effects related to white matter and gray matter at 9.4T. We apply an analytical presentation of the diffusion-modified frequency distribution, previously only used for gradient and spin echoes, to bSSFP and we prove the applicability of this theory to bSSFP by Monte Carlo simulations and measurements.

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