Abstract #5277

Is Iron Concentration Linked to Structural Connectivity in the Subthalamic Nucleus? Implications for Planning of Deep Brain Stimulation

Wahaj Patel^1,2, Alexey Dimov³, Yi Wang³, Yihang Yao³, Brian Kopell^4,5, and Rafael O’Halloran^1,4

¹Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²The City College of New York, New York, NY, United States, ³Weill Cornell Medical College, ⁴Psychiatry, Icahn School of Medicine at Mount Sinai, ⁵Neurosurgery, Icahn School of Medicine at Mount Sinai

The relationship between iron concentration, evaluated via quantitative susceptibility mapping (QSM) and white matter connectivity, assessed with 3T MRI, was explored. Such a relationship might be useful in deep brain stimulation (DBS) surgical planning, where both QSM and white matter connectivity are gaining interest. For several relevant regions of interest in movement disorders such as the superior frontal, pre central and post central gyrus there was a strong correlation between STN connectivity and QSM intensity. To allow quick assessment of the spatial variation of connectivity in the STN, an RGB image was computed from connectivity in 3 regions of interest.

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