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Abstract #5282

Accelerated intermittent theta burst stimulation, applied to the left DLPFC, influences dynamics in depression related networks

Debby Klooster1,2,3, Rene Besseling1,2,3, Suzanne Franklin1, Antoine Bernas1, Romain Duprat2, Albert Aldenkamp1,2,3, and Chris Baeken2

1Eindhoven University of Technology, Eindhoven, Netherlands, 2University Hospital Ghent, Ghent, Belgium, 3Academic Center for epileptology Kempenhaeghe, Heeze, Netherlands

The effect of accelerated intermittent theta burst stimulation (aiTBS) is investigated in three resting-state networks involved in depression: default mode network (DMN), central executive network (CEN), and salience network (SN). Multivariate Granger causality analysis was performed between time-series representing each network and between time-series of nodes belonging to these networks. The effects of the latter analysis were quantified by the in- and out-degree. No between-network effects were found but specific connections showed increased or decreased Granger causality after stimulation. Clinical responders showed changes in the in- and out-degree of the anterior cingulate, known to be important in depression pathology.

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