In this study, we combined resting-state functional magnetic resonance imaging (rsfMRI) and advanced magnetic resonance spectroscopy technique to demonstrate a positive relationship between levels of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) within posterior cingulate cortex/precuneus (PCC/PCu) and high network centrality of primary network. High network centrality propagates and contributes to efficient information flow in brain network. The PCC/PCu is a key component of default mode network (DMN) and high regional GABA levels expressing in the PCC/PCu area deactivate DMN activities related to internal thoughts for reallocating attention resources from internal processes to goal directed external stimuli with high network centrality.
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