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Abstract #5304

Effects of anesthesia on BOLD, electrophysiology, and PO2 signals in the whisker barrel cortex

Daniil P Aksenov1, Limin Li1, Michael Miller1, Robert Linsenmeier2, and Alice M Wyrwicz1

1NorthShore University HealthSystem, Evanston, IL, United States, 2Northwestern University, Evanston, IL, United States

A comprehensive understanding of the relationship between neuronal activity and oxygen dynamics in the brain is vital for the accurate interpretation of fMRI results. This study investigates the relationship between changes in blood and tissue oxygen as well as neuronal activity in the awake and anesthetized states. We compare BOLD, PO2 and electrophysiological signals in the barrel cortex during whisker stimulation in awake and isoflurane-anesthetized rabbits. Our findings suggest that the relationship between BOLD, PO2 and electrophysiological responses is considerably different in the awake and anesthetized states.

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