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Abstract #5305

Quantitative Mapping of Cerebrovascular Reactivity using Resting-state BOLD fMRI: A Validation in Healthy Adults

Ali Golestani1, Luxi Wei2, and Jean Chen2,3

1Department of Psychology, University of Toronto, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Rotman Research Institute at Baycrest, Toronto, ON, Canada

Cerebrovascular reactivity (CVR) is commonly mapped as the response of the blood oxygenation level dependent (BOLD) signal to a hyper/hypocapnic breathing challenge, which might be intolerable for some patients. We proposed a method to estimate quantitative CVR using intrinsic fluctuations of end-tidal CO2 (PETCO2) during resting-state fMRI data acquisition (rs-qCVR). We validated our rs-qCVR method against the “gold-standard” hyper/hypocapnic CVR method, demonstrating significantly association between the two in the majority of the healthy subjects.

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