Abstract #5305

Quantitative Mapping of Cerebrovascular Reactivity using Resting-state BOLD fMRI: A Validation in Healthy Adults

Ali Golestani¹, Luxi Wei², and Jean Chen^2,3

¹Department of Psychology, University of Toronto, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Rotman Research Institute at Baycrest, Toronto, ON, Canada

Cerebrovascular reactivity (CVR) is commonly mapped as the response of the blood oxygenation level dependent (BOLD) signal to a hyper/hypocapnic breathing challenge, which might be intolerable for some patients. We proposed a method to estimate quantitative CVR using intrinsic fluctuations of end-tidal CO₂ (PETCO₂) during resting-state fMRI data acquisition (rs-qCVR). We validated our rs-qCVR method against the “gold-standard” hyper/hypocapnic CVR method, demonstrating significantly association between the two in the majority of the healthy subjects.

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