Abstract #5306

Comparison of Quantitative Specific Ventilation Imaging in the Lung with Oxygen Enhanced 1H and 3He Multibreath MRI

Tatsuya J Arai^1,2,3, Felix C Horn², Rui Carlos Sá³, Madhwesha R Rao², Guilhem Collier², Rebecca J Theilmann³, G. Kim Prisk³, and Jim M Wild²

¹UT Southwestern Medical Center, Dallas, TX, United States, ²Academic Unit of Radiology, The University of Sheffield, Sheffield, United Kingdom, ³Pulmonary Imaging Laboratory, University of California, San Diego, San Diego, CA, United States

Two multi-breath imaging techniques for quantifying specific ventilation based on oxygen enhanced ¹H and hyperpolarized 3He gas MRI were cross-validated with spatially matched data from the same subjects. With a custom RF torso ¹H array configured with³He T-R coil in situ we were able to separately acquire ¹H and hyperpolarized ³He MRI during a single scanning session without repositioning the subject. The preliminary study demonstrated qualitative as well as quantitative similarities between the two techniques.

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