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Abstract #5307

Quantification of Neural Energetic Changes during Visuomotor Learning using Arterial Spin Labelling FMRI

Catherine Foster1, Jessica Steventon1,2, Ian Driver1, Daniel Helme1, Valentina Tomassini3, and Richard G Wise1

1School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 2School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff, United Kingdom, 3School of Medicine, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff, United Kingdom

Recovery of motor function following neurological damage is dependent on functional neuroplasticity. Mechanisms of adaptive plasticity are not well understood, thus limiting the ability to predict recovery following rehabilitation. This study examined the suitability of calibrated fMRI to study cerebrovascular changes during motor learning, as cerebrovascular function plays an important role in neuroplasticity. Results showed cerebral blood flow, BOLD and oxygen metabolism increases from rest with task but decreases with task-learning. However, high inter-subject response variability was observed. Calibrated fMRI shows promise for studying cerebrovascular changes during learning but the repeatability and stability of measurements requires further investigation.

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