Abstract #5309

Comparison of BH CVR and resting state fMRI to “gold standard” task-based fMRI for assessment of brain tumor-induced neurovascular uncoupling

Shruti Agarwal¹, Haris I. Sair¹, Sachin Gujar¹, Arvind P. Pathak ^1,2, and Jay J. Pillai¹

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Dept. of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Neurovascular Uncoupling (NVU) can critically limit presurgical mapping using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI). False-negative activations caused by NVU can lead to erroneous interpretation of clinical fMRI examinations. Brain tumor-related NVU has been previously demonstrated on task-based BOLD fMRI (tbfMRI) and resting state BOLD fMRI (rsfMRI). The purpose of this study is to demonstrate that NVU in the sensorimotor network can be similarly detected on rsfMRI and BH CVR maps as evident in the criterion standard tbfMRI.

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