Abstract #5310

Pharmacological inactivation of dorsal hippocampus enhances responses and induces adaptation to sound in midbrain

Celia M. Dong^1,2, Russell W. Chan^1,2, Leon C. Ho^1,2, Alex T.L. Leong^1,2, Eddie Wong^1,2, Lei Wang^1,2,3, Felix F. Chen³, Condon Lau⁴, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen, People's Republic of China, ⁴Department of Physics and Materials Science, City University of Hong Kong, Hong Kong, Hong Kong

The hippocampus is associated with the memory and learning, meanwhile, receives signal from all sensory system indirectly. However, whether and how the hippocampus influences sound processing in the auditory system remains unclear. Our recent study showed that optogenetic stimulation of hippocampus enhances the brain bilateral auditory cortex connectivity. This fMRI study investigated the influence of hippocampus on auditory processing in the inferior colliculus (IC) by using tetrodotoxin (TTX) to pharmacologically deactivate the dorsal hippocampus. For the first time, our results revealed that the dorsal hippocampus plays a dynamic role in shaping the IC auditory response.

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