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Abstract #5315

Functional MRI of Brain's White Matter in Alzheimer's Disease

Xiaowei Song1,2, Hui Guo1,3, Sujoy Ghosh-Hajra2, Careesa Liu2, Yunting Zhang3, and Ryan CN D'Arcy1,2

1Health Sciences and Innovation, Fraser Health Authority, Surry, BC, Canada, 2Simon Fraser University, Burnaby, BC, Canada, 3Medical Imaging, Tianjin Medical University General Hospital, Tianjin, People's Republic of China

Impaired white matter (WM) integrity is common in Alzheimer's disease (AD), in addition to gray matter degeneration. While fMRI has been widely used in understanding the disease-associated changes, results so far have omitted the WM even though WM activation has repeatedly been reported in healthy younger adults in recent fMRI studies. Here we applied three tasks targeting interhemispheric transfer at 3.0T to extend the WM fMRI research to clinical applications in AD-dementia. The study detected fMRI activation in the corpus callosal WM in 87% individuals with early AD and normal cognitive aging (NC), and a difference between AD and NC.

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