The phenomenon of neurovascular uncoupling (NVU) is an under-recognized but very important limitation of clinical BOLD fMRI because it can lead to non-visualization of eloquent cortex and resultant inadvertent surgical resection of vital brain tissue leading to permanent postoperative disability. In this study we demonstrate a novel method for correcting for the spuriously decreased ipsilesional motor activation associated with NVU through use of a novel resting state fMRI (rsfMRI) frequency domain metric-- ALFF (amplitude of low-frequency fluctuation)-- in patients with perirolandic low grade gliomas.
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