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Abstract #5314

fMRI activation optimization in the setting of brain tumor-induced neurovascular uncoupling using resting state BOLD ALFF

Shruti Agarwal1, Hanzhang Lu1, and Jay J. Pillai1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The phenomenon of neurovascular uncoupling (NVU) is an under-recognized but very important limitation of clinical BOLD fMRI because it can lead to non-visualization of eloquent cortex and resultant inadvertent surgical resection of vital brain tissue leading to permanent postoperative disability. In this study we demonstrate a novel method for correcting for the spuriously decreased ipsilesional motor activation associated with NVU through use of a novel resting state fMRI (rsfMRI) frequency domain metric-- ALFF (amplitude of low-frequency fluctuation)-- in patients with perirolandic low grade gliomas.

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