In brain tumor patients, coupling between neuronal activity and BOLD response is often disrupted (known as neurovascular uncoupling (NVU)), resulting in dangerous underestimation of true extent of eloquent cortex in pre-surgical planning. With increasing popularity of resting state fMRI (rsfMRI) for presurgical mapping, it becomes critical to investigate effects of NVU in rsfMRI. A recent study demonstrated that tumor-related NVU can impact resting state functional connectivity within the sensorimotor network as assessed using a seed-based correlation analysis (SCA).2 We now explore whether NVU may also affect the rsfMRI frequency domain metrics ALFF (amplitude of low-frequency fluctuation) & fALFF (fractional ALFF).
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