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Abstract #5326

Value of frequency domain resting state fMRI metrics ALFF & fALFF in the assessment of brain tumor induced neurovascular uncoupling

Shruti Agarwal1, Hanzhang Lu1, and Jay J. Pillai1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

In brain tumor patients, coupling between neuronal activity and BOLD response is often disrupted (known as neurovascular uncoupling (NVU)), resulting in dangerous underestimation of true extent of eloquent cortex in pre-surgical planning. With increasing popularity of resting state fMRI (rsfMRI) for presurgical mapping, it becomes critical to investigate effects of NVU in rsfMRI. A recent study demonstrated that tumor-related NVU can impact resting state functional connectivity within the sensorimotor network as assessed using a seed-based correlation analysis (SCA).2 We now explore whether NVU may also affect the rsfMRI frequency domain metrics ALFF (amplitude of low-frequency fluctuation) & fALFF (fractional ALFF).

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