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Abstract #5327

The resting state fMRI regional homogeneity (ReHo) metrics KCC-ReHo & Cohe-ReHo are valid indicators of tumor-related neurovascular uncoupling

Shruti Agarwal1, Haris I. Sair1, and Jay J. Pillai1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The validity of BOLD fMRI in pre-surgical planning may be severely compromised due to disruption of the normal coupling between neural activity and the consequent microvascular blood flow response (neurovascular uncoupling, or NVU). The effects of brain tumor-induced NVU on resting state BOLD fMRI (rsfMRI) have been previously described through seed-based correlation analysis (SCA). In this study, we evaluated regional homogeneity of resting state fMRI data using Kendall's coefficient of concordance (KCC-ReHo) & Coherence (Cohe-ReHo) metrics and compared these results with those of “gold standard”motor task-based (tbfMRI) activation to determine their effectiveness in detecting NVU in the sensorimotor network.

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