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Abstract #5359

Characteristics of brain spontaneous neuronal activity in chronic alcoholics using different resting-state fMRI algorithm

Yilin Zhao1, Jun Chen1, and Hui Lin2

1Radiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China, 2GE Healthcare, GE MR Research China, People's Republic of China

Resting-state fMRI reflected spontaneous baseline neuronal activity.The fractional amplitude of low frequency fluctuation (fALFF) and regional homogeneity(ReHo) method had been developed to analyze the blood oxygenation level-dependent signal fluctuations in voxelwise analysis across the whole brain.In this study, we combined two resting-state fMRI algorithm to explore the features of brain spontaneous activities in chronic alcoholics.The results indicated the abnormality activities of some nodes in the default mode network and reward circuit. It is our hope that in future studies this technique may provide the opportunity to examine the integrity of networks involving the above loops in chronic alcoholics.

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