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Abstract #5360

BOLD-fMRI evaluation of analgesic effects on allodynia-specific pain using fibromyalgia model rats

Sosuke Yoshinaga1, Naoya Yuzuriha1, Yuri Kitamoto1, Mitsuhiro Takeda1, Hiroshi Sato2, and Hiroaki Terasawa1

1Department of Structural BioImaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 2Bruker BioSpin K.K., Yokohama, Japan

The aim of this study is to evaluate the effects of analgesic agents on the allodynia-specific response in an animal model of fibromyalgia. Before and after the treatment with analgesic agents, BOLD experiments using green laser stimulation were performed. Before the treatments with analgesic agents, S1, IC, and TH exhibited BOLD responses (S1: 1.1%, IC: 0.8%, TH: 0.7%). These responses were inhibited by pregabalin treatment and to a lesser extent by duloxetine treatment (S1: 0.4%, IC: not detected, TH: 0.4%). Our experimental system provides a robust preclinical and clinical evaluation system for new analgesic agents.

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