The aim of this study is to evaluate the effects of analgesic agents on the allodynia-specific response in an animal model of fibromyalgia. Before and after the treatment with analgesic agents, BOLD experiments using green laser stimulation were performed. Before the treatments with analgesic agents, S1, IC, and TH exhibited BOLD responses (S1: 1.1%, IC: 0.8%, TH: 0.7%). These responses were inhibited by pregabalin treatment and to a lesser extent by duloxetine treatment (S1: 0.4%, IC: not detected, TH: 0.4%). Our experimental system provides a robust preclinical and clinical evaluation system for new analgesic agents.
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