Abstract #5386

White Matter Resting-State fMRI with Hypercapnic Respiratory Challenge

Tung-Lin Wu^1,2, Jennifer Watchmaker¹, Li Min Chen^1,3, Adam W Anderson^1,2,3, Zhaohua Ding^1,2,3, and John C Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

In order to further elucidate the biophysical origins of spatio-temporal correlation tensors and validate the possibility of detecting BOLD signals in white matter, we acquired resting-state fMRI in volunteers breathing alternately room air and CO₂ enriched air to induce a hypercapnic-normoxic change in CBF and CBV. Our hypercapnic respiratory challenge experiments suggest that spatio-temporal correlations in white matter may be driven by local hemodynamic effects, consistent with BOLD effects instead of other potential mechanisms. Our results also imply and support our previous observation that BOLD signals in white matter can be reliably detected, and resting-state correlations between voxels are anisotropic.

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