Abstract #5388

Stimulus-evoked fMRI activations are a subset of resting-state fMRI networks in the rat olfactory bulb

Garth J Thompson^1,2, Basavaraju G Sanganahalli^1,2,3, Keeley Baker^4,5, Justus V Verhagen^4,5, Gordon M Shepherd⁵, and Fahmeed Hyder^1,2,3,6

¹Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, United States, ³Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, Yale University, New Haven, CT, United States, ⁴The John B. Pierce Laboratory, New Haven, CT, United States, ⁵Neurobiology, Yale University, New Haven, CT, United States, ⁶Biomedical Engineering, Yale University, New Haven, CT, United States

Are coordinated activations of the brain during sensory stimulation linked to the synchronized activations or “functional connectivity” observed with resting state fMRI? We recorded odor-stimulation fMRI and resting state fMRI in the rat olfactory bulb’s glomerular sheet. Glomerular activations due to three odors were compared to spontaneous fluctuations organized as twenty-two independent component networks. Networks correlated with activation in an odor-specific manner. We reconstructed approximations of activation which retained odor specificity for two of three odors, despite being constructed from resting state data. Our results suggest a function for synchronized resting oscillations in reinforcing stimulation-specific responses.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.