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Abstract #5389

Dynamic Functional Connectivity in Event-Related fMRI and its implications in Epilepsy

Ashish Kaul Sahib1,2, Michael Erb1, Klaus Scheffler1,3, Thomas Ethofer1,4, and Niels Focke2

1Department of Biomedical Magnetic Resonance, University Hospital tuebingen, Tuebingen, Germany, 2Department of Neurology/Epileptology, University Hospital tuebingen, Tuebingen, Germany, 3Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany, 4Department of General Psychiatry, University Hospital tuebingen, Tuebingen, Germany

To assess the impact of repetition time (TR) and window size on the temporal features of BOLD functional connectivity (FC) using a sliding window approach in event-related fMRI. in addition, test the feasibility of this approach in epilepsy. We calculated the functional connectivity degree (FCD) by counting the total number of connections of a given voxel above a predefined threshold based on Pearson correlation. In summary, we showed that dynamic FCD transients are better detectable with sub-second TR than conventional TR, indicating a potential to study the temporal characteristics of interictal epileptiform discharges and seizures in epilepsy patients.

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