Abstract #5401

Low frequency activity from somatosensory thalamus propagates brain-wide and modulates top-down visual processing

Alex T. L. Leong^1,2, Russell W. Chan^1,2, Xunda Wang^1,2, Celia M. Dong^1,2, Leon C. Ho^1,2, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong

Top-down/descending control is a critical stage in sensory processing that underlies numerous cognitive processes. Recent studies uncovered the prevalence of converging long-range networks across multiple sensory modalities as anatomical substrates that likely mediate sensory top-down control. Using an optogenetic fMRI technique that we recently developed to examine patterns of large-scale brain-wide interactions mediated by the somatosensory thalamo-cortical network, we demonstrated that propagating low frequency activity (~1Hz) underlying such interactions enhanced visual responses in the superior colliculus. This work presents a new approach to investigate the functional roles of top-down control and their underlying brain mechanisms.

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