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Abstract #5403

Simultaneous trimodal MR-flumazenil-PET-EEG imaging in a rest-task-rest design in humans

Irene Neuner1,2,3,4, Ravichandran Rajkumar1,2,3,4, Praveen Sripad1, Christine Wyss1,4,5, Jörg Mauler1, Lutz Tellmann1, Elena Rota Kops1, Jürgen Scheins1, Markus Lang6, Frank Boers1, Christoph Lerche1,4, Johannes Ermert6, Bernd Neumaier6, Jürgen Dammers1, Karl-Josef Langen1,7, Hans Herzog1, Wolfram Kawohl4,5, and N Jon Shah1,3,4,8,9

1Institute of Neuroscience and Medicine 4 (INM4), Forschungszentrum Juelich GmbH, Juelich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA – BRAIN – Translational Medicine, Juelich, Germany, 4TRIMAGE-consortium, Juelich, Germany, 5Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland, 6Institute of Neuroscience and Medicine 5 (INM5), Forschungszentrum Juelich GmbH, Juelich, Germany, 7Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 8Department of Neurology, RWTH Aachen University, Aachen, Germany, 9Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

How quickly does the human brain switch back from a task mode to the resting state condition? This question is addressed in a small sample of healthy volunteers employing a simultaneous trimodal MR-flumazenil-PET-EEG approach at 3T. Based on the fMRI results, we observe an increase in ReHo - a measure of local connectivity - coupled with a slight decrease in the binding potential of [11C] Flumazenil in the PCC which is a major hub of the default mode network; this indicates a change of the GABA-ergic driven inhibitory tonus. This is accompanied with changes in the alpha band over parietal electrodes.

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