Abstract #5403

Simultaneous trimodal MR-flumazenil-PET-EEG imaging in a rest-task-rest design in humans

Irene Neuner^1,2,3,4, Ravichandran Rajkumar^1,2,3,4, Praveen Sripad¹, Christine Wyss^1,4,5, Jörg Mauler¹, Lutz Tellmann¹, Elena Rota Kops¹, Jürgen Scheins¹, Markus Lang⁶, Frank Boers¹, Christoph Lerche^1,4, Johannes Ermert⁶, Bernd Neumaier⁶, Jürgen Dammers¹, Karl-Josef Langen^1,7, Hans Herzog¹, Wolfram Kawohl^4,5, and N Jon Shah^1,3,4,8,9

¹Institute of Neuroscience and Medicine 4 (INM4), Forschungszentrum Juelich GmbH, Juelich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, Juelich, Germany, ⁴TRIMAGE-consortium, Juelich, Germany, ⁵Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland, ⁶Institute of Neuroscience and Medicine 5 (INM5), Forschungszentrum Juelich GmbH, Juelich, Germany, ⁷Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁸Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁹Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

How quickly does the human brain switch back from a task mode to the resting state condition? This question is addressed in a small sample of healthy volunteers employing a simultaneous trimodal MR-flumazenil-PET-EEG approach at 3T. Based on the fMRI results, we observe an increase in ReHo - a measure of local connectivity - coupled with a slight decrease in the binding potential of [¹¹C] Flumazenil in the PCC which is a major hub of the default mode network; this indicates a change of the GABA-ergic driven inhibitory tonus. This is accompanied with changes in the alpha band over parietal electrodes.

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