Abstract #5404

GABA MRS combined with resting state functional connectivity to explore decoding and fluency skills of typical and struggling readers

Lisa C. Krishnamurthy^1,2,3, Venkatagiri Krishnamurthy^2,3,4, Dina M. Schwam⁵, Daphne Greenberg⁵, and Robin D. Morris^3,6

¹Dept. of Physics & Astronomy, Georgia State University, Atlanta, GA, United States, ²Center for Visual and Neurocognitive Rehabilitation, Atlanta VAMC, Decatur, GA, United States, ³Center for Advanced Brain Imaging, GSU/GT, Atlanta, GA, United States, ⁴Dept. of Neurology, Emory University, Atlanta, GA, United States, ⁵Dept. of Educational Psychology, Special Education, and Communication Disorders, Georgia State University, Atlanta, GA, United States, ⁶Dept. of Psychology, Georgia State University, Atlanta, GA, United States

Previous reports have shown that resting concentrations of gamma-amino butyric acid (GABA) will predict resting state Functional Connectivity (rsFC) measures as well as amplitude of task activation. The goal of this study is to model how the neurochemical profile interplays with the connectivity underlying the decoding and fluency components of the reading circuit. Our model is in support of recent task-based fMRI observations, but goes beyond by interrogating the underlying networks that support the behavior, and combining that information with the neurochemistry that characterize the trait. These preliminary results of combining MRS and rsFC with neuropsychological measures are promising, and will help identify the underlying dysfunction in struggling adult readers’ brain circuitry.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.